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ANTIOXIDANT 1010
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Ethylene Glycol
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Formic Acid
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Glycolic acid
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Isopropyl Alcohol
Limestone powder
Methyl Alcohol
Methylene Chloride
Moisture absorber
Nitric acid
NP-9
OB1 masterbatch
OBSH BLOWING AGANT
Oxalic acid
Oxidized polyethylene wax
PE wax
Phosphoric Acid
Pigment paste
Plasticizer
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Processing aid
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Purging agent
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Titanium Dioxide Paste
Tribasic Leadsulphate
Trichloroethylene
Trisodium Phosphate
Zinc Oxide
Zinc Stearate
Citric acid
C6H8O7
CAS No.25213-24-5
PVA
POVAL
Na2SiO3
TRONOX CR834
Waterglass
Sodium Silicate
Sodium Metasilicate
Methylenedianiline
2-Hydroxyethylamine
Sodium Siligate
DDM
เมทิลีนไดอะนิลีน
MEA
เอทาโนลามีน
Carbon Black N660
Urea46
คาร์บอนแบล็ก N660
คาร์บอนแบล็ค N660
carbonyldiamine
diaminomethanone
เอ็นเอ็มพี
เอ็น-เมทิล-2-ไพโรลีโดน
เอ็น-เมทธิล-2-ไพโรลีโดน
เมธิลไพโรลิโดน
เมธิลไพร์โรลิโดน
เมทิลไพโรลิโดน
เมทิลไพร์โรลิโดน
เมทธิลไพโรลิโดน
เมทธิลไพร์โรลิโดน
นอร์มอลเมธิลไพโรริโดน
นอร์มอลเมทิลไพโรริโดน
นอร์มอลเมทธิลไพโรริโดน
NMP
N-Methyl-2-pyrrolidone
Methylpyrrolidone
C5H9NO , CAS number 872-50-4
หินเกล็ดคัดขนาด
BLR 699
SACTLEBEN RD3
Phosphoric acid
โพรไพลีนไกลคอล
Citric acid anhydrous
Malic acid
Xanthan Gum
Blancfixe
Precipitated Barium Sulfate
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Precipitated Barium Sulphate
Ground Barium Sulphate
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Baryte 350
Baryte 400 mesh
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Precipitated Baryte
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Xanthan Gum Europe
Xanthan Gum FCC
Xanthan Gum Food Grade
Xanthan Gum Jungbunzlauer
Xanthan Gum Pharmaceutical Grade
Xanthan Gum USP
แซนแทนกัม Jungbunzlauer
แซนแทนกัมเกรดยา
แซนแทนกัมเกรดอาหาร
แซนแทนกัมยุโรป
Calcium Hydroxide FCC
Calcium Hydroxide food grade
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Calcium Hydroxide Pharmaceutical Grade
Calcium Hydroxide USP grade
CaOH2 FCC
CaOH2 food grade
CaOH2 Pharma grade
CaOH2 Pharmaceutical Grade
CaOH2 USP grade
Hydrated Lime FCC
Hydrated Lime food grade
Hydrated Lime Pharma grade
Hydrated Lime Pharmaceutical Grade
Hydrated Lime USP grade
SCHAEFER Hydrated lime
SCHAEFER PRECAL
แคลเซียมคาร์บอเนตฟู้ดเกรด
แคลเซียมคาร์บอเนตฟูดส์เกรด
แคลเซียมฟู้ดเกรด
แคลเซียมฟูดส์เกรด
แคลเซียมไฮดรอกไซด์เกรดยา
แคลเซียมไฮดรอกไซด์เกรดอาหาร
แคลเซียมไฮดรอกไซด์ฟู้ดเกรด
แคลเซียมไฮดรอกไซด์ฟูดส์เกรด
ปูนขาว Food grade
ปูนขาว Pharmaceutical Grade
ปูนขาว PRECAL
ปูนขาว SCHAEFER
ปูนขาวเกรดยา
ปูนขาวเกรดอาหาร
ปูนขาวฟู้ดเกรด
ปูนขาวฟูดส์เกรด
ไฮเดรตไลม์เกรดยา
ไฮเดรตไลม์เกรดอาหาร
ไฮเดรตไลม์ฟู้ดเกรด
ไฮเดรตไลม์ฟูดส์เกรด
HEDP, เอชอีดีพี, Hydroxy ethylidene diphosphonic acid
Magnesium Stearate
พาราฟินแวกซ์ฟูลลี่รีไฟน์ , Paraffin Wax Fully Refined
แมกนีเซียมสเตียเรต
แมกนีเซียมสเตียเรท
Ammonium Chloride
Borax
Butyl CARBITOL
Butyl CELLOSOLVE
DEGME
Diethylene Glycol Monomethyl
EGBE
Ether
Ethylene Glycol Monobutyl Ether
NaCl
Sodium Chloride
กรดบอริค
เกลือกลาง
เกลือแก้ว
เกลือขาว
เกลือดำ
เกลือทะเล
เกลือเม็ด
เกลือสมุทร
โซเดียมคลอไรด์
ดีอีจีเอ็มอี
ไดเอทิลีนไกลคอลโมโนเมทิลอีเทอร์
บอริคแอซิด
บอแรกซ์
บิวทิลคาร์บิทอล
บิวทิลเซลโลโซล์ฟ
อีจีบีอี
เอทิลีนไกลคอลโมโนบิวทิลอีเทอร์
แอมโมเนียมคลอไรด์
HIMATEX,SNOBRITE,HIMAFIL,HIMAFINE
POLYGLYCOL P425,POLYGLYCOL P-425,CAS No. 25322-69-4
Polypropylene glycols,PPGs,Polypropylene Oxide
เกาลิน,เคโอลิน,Kaolin
เกาลินเคลย์,Kaolin clay
แคลไซน์เกาลิน,Calcine Kaolin
แคลไซน์เคลย์,Calcine Clay
ไชน่าเคลย์,China Clay
พีพีจี,PPG,โพลีโพรพิลีนไกลคอล
โพลีไกลคอล,Polyglycol,PPG425
โพลีโพรไพลีนไกลคอล,Polypropylene glycol
โพลีโพรไพลีนออกไซด์,โพลีโพรพิลีนออกไซ&#
อลูมิเนียมซิลิเกต,Aluminium Silicate
ไฮดรัสเคลย์,Hydrous Clay
ไฮดรัสอลูมิเนียมซิลิเกต,Hydrous Aluminium Silicate
4K Mica, ไมก้า4K
Alumina Silicate
KMPM Kaolin, เคเอ็มพีเอ็มเกาลิน
Mica
Muscovite Mica
Potassium Aluminium Silicate
Sericite, CAS No. 12001262
โพแทสเซียมอลูมิเนียมซิลิเกต
ไมก้า
อลูมินาซิลิเกต
Acetic acid ethyl ester
Acetic Ester, อะซีติกเอสเทอร์
C4H8O2, CAS No. 141786
Ethyl Acetate
Ethyl Ethanoate, เอทิลเอทาโนเอต
อะซีติกแอซิดเอทธิลเอสเตอร์
เอตทิลอะซิเตต
เอทธิลอะซีเตต
เอทธิลอะซีเตท
เอทธิลอะซีเทต
เอทิลอะซิเตท
เอทิลอะซีเตต
เอธิลอะซีเตต
Aliphatic Hydrocarbon Resin
C5 Resin, เรซิ่น C5, CAS No. 220543679
Hydrocarbon Resin
Petroleum Resin
Piperlene Resin, Piperylene Resin
Quintone Resin
Thermoplastic Resin
เทอร์โมพลาสติกเรซิ่น
ปิโตรเลียมเรซิ่น
ไฮโดรคาร์บอนเรซิ่น
ไดเอทิลีนไกลคอลโมโนบิวทิลอีเทอร์
ไดเมทิลฟอร์มาไมด์
พลาสติไซเซอร์ปลอดสารพทาเลต
เอทิลีนไวนิลอะซีเตต
โพลีเอทิลีนไกลคอล 4000
Calcium Nitrate
Cyclohexanone
Diacetone Alcohol
Butyl Diglycol
Butyl Acetate
Methyl Ethyl Ketone
Methyl Isobutyl Ketone
Magnesium Oxide
Acetone
EVA
Boraxpentahydrate, Boraxdecahydrate
Neobor Borax
PERC
Perchloroethylene
Tetrachloroethylene
Base oil
Deep Chrome Yellow
Nonylphenolethoxylate
Chlorine Solution
Sodium Hypochlorite
โนนิลฟีนอลอีทอกซีเลท
Magnesium Chloride
Glass Bead
Yellow pigment
Hydrogentperoxide
TPCC AEC
 

Polyether Glycol

โพลีอีเทอร์ไกลคอล, โพลีเอทิลีนไกลคอล, Polyether Glycol, Polyethylene Glycol, PEG

คาร์โบแวกซ์, CARBOWAX, PEG 100, PEG 200, PEG 300, PEG 400, PEG 600, PEG 1000

Polyethylene glycol (PEG) is a polyether compound with many applications from industrial manufacturing to medicine. It has also been known as polyethylene oxide (PEO) or polyoxyethylene (POE), depending on its molecular weight, and under the tradename Carbowax. PEG, PEO, or POE refers to an oligomer or polymer of ethylene oxide. The three names are chemically synonymous, but historically PEG has tended to refer to oligomers and polymers with a molecular mass below 20,000 g/mol, PEO to polymers with a molecular mass above 20,000 g/mol, and POE to a polymer of any molecular mass.[2] PEG and PEO are liquids or low-melting solids, depending on their molecular weights. PEGs are prepared by polymerization of ethylene oxide and are commercially available over a wide range of molecular weights from 300 g/mol to 10,000,000 g/mol. While PEG and PEO with different molecular weights find use in different applications and have different physical properties (e.g., viscosity) due to chain length effects, their chemical properties are nearly identical. Different forms of PEG are also available dependent on the initiator used for the polymerization process, the most common of which is a monofunctional methyl ether PEG (methoxypoly(ethylene glycol)), abbreviated mPEG. Lower-molecular-weight PEGs are also available as purer oligomers, referred to as monodisperse, uniform or discrete. Very high purity PEG has recently been shown to be crystalline, allowing determination of an xray crystal structure.[3] Since purification and separation of pure oligomers is difficult, the price for this type of quality is often 10-1000 fold that of polydisperse PEG. PEGs are also available with different geometries. Branched PEGs have three to ten PEG chains emanating from a central core group. Star PEGs have 10–100 PEG chains emanating from a central core group. Comb PEGs have multiple PEG chains normally grafted to a polymer backbone. Their melting points vary depending on the Formula Weight of the polymer. PEG or PEO has the following structure. The numbers that are often included in the names of PEGs indicate their average molecular weights, e.g., a PEG with n=9 would have an average molecular weight of approximately 400 daltons and would be labeled PEG 400. Most PEGs include molecules with a distribution of molecular weights; i.e., they are polydisperse. The size distribution can be characterized statistically by its weight average molecular weight (Mw) and its number average molecular weight (Mn), the ratio of which is called the polydispersity index (Mw/Mn). Mw and Mn can be measured by mass spectrometry.

Polyethylene glycol (PEG) is a polyether compound with many applications from industrial manufacturing to medicine. The structure of PEG is (note the repeated element in parentheses):  H-(O-CH2-CH2)n-OH

PEG is also known as polyethylene oxide (PEO) or polyoxyethylene (POE), depending on its molecular weight.

Production

Polyethylene glycol is produced by the interaction of ethylene oxide with water, ethylene glycol, or ethylene glycol oligomers.[5] The reaction is catalyzed by acidic or basic catalysts. Ethylene glycol and its oligomers are preferable as a starting material instead of water, because they allow the creation of polymers with a low polydispersity (narrow molecular weight distribution). Polymer chain length depends on the ratio of reactants.

 HOCH2CH2OH + n(CH2CH2O) HO(CH2CH2O)n+1H

Depending on the catalyst type, the mechanism of polymerization can be cationic or anionic. The anionic mechanism is preferable because it allows one to obtain PEG with a low polydispersity. Polymerization of ethylene oxide is an exothermic process. Overheating or contaminating ethylene oxide with catalysts such as alkalis or metal oxides can lead to runaway polymerization, which can end in an explosion after a few hours.

Polyethylene oxide, or high-molecular weight polyethylene glycol, is synthesized by suspension polymerization. It is necessary to hold the growing polymer chain in solution in the course of the polycondensation process. The reaction is catalyzed by magnesium-, aluminium-, or calcium-organoelement compounds. To prevent coagulation of polymer chains from solution, chelating additives such as dimethylglyoxime are used.

Alkali catalysts such as sodium hydroxide (NaOH), potassium hydroxide (KOH), or sodium carbonate (Na2CO3) are used to prepare low-molecular-weight polyethylene glycol.

Medical uses

PEG is the basis of a number of laxatives (e.g., macrogol-containing products, such as Movicol and polyethylene glycol 3350, or SoftLax, MiraLAX,ClearLAX, or GlycoLax). Whole bowel irrigation with polyethylene glycol and added electrolytes is used for bowel preparation before surgery or colonoscopy. The preparation is sold under the brand names GoLYTELY, GaviLyte C, NuLytely, GlycoLax, Fortrans, TriLyte, Colyte, Halflytely, Softlax, Lax-a-Day, ClearLax and MoviPrep. In the United States, MiraLAX and Dulcolax Balance are sold without prescription for short-term relief of chronic constipation. Miralax is currently FDA approved for adults for a period of seven days, and is not approved for children.  A 2007 comparison showed that patients suffering from constipation had a better response to PEG medications than to tegaserod. These medications soften the fecal mass by osmotically drawing water into the GI tract. It is generally well tolerated, however, side effects are possible bloating, nausea, gas, and diarrhea (with excessive use).

When attached to various protein medications, polyethylene glycol allows a slowed clearance of the carried protein from the blood. This makes for a longer-acting medicinal effect and reduces toxicity, and allows longer dosing intervals. Examples include PEG-interferon alpha, which is used to treat hepatitis C, and PEGfilgrastim (Neulasta), which is used to treat neutropenia. It has been shown that polyethylene glycol can improve healing of spinal injuries in dogs. One of the earlier findings, that polyethylene glycol can aid in nerve repair, came from the University of Texas (Krause and Bittner). Polyethylene glycol is also commonly used to fuse B-cells with myeloma cells in monoclonal antibody production. PEG is used as an excipient in many pharmaceutical products. Lower-molecular-weight variants are used as solvents in oral liquids and soft capsules, whereas solid variants are used as ointment bases, tablet binders, film coatings, and lubricants.

PEG is also used in lubricating eye drops.

Research for new clinical uses

 PEG, when labeled with a near-infrared fluorophore, has been used in preclinical work as a vascular agent, lymphatic agent, and general tumor-imaging agent by exploiting the Enhanced permeability and retention effect (EPR) of tumors. High-molecular-weight PEG (e.g. PEG 8000) has been shown to be a dietary preventive agent against colorectal cancer in animal models. The Chemoprevention Database shows PEG is the most effective known agent for the suppression of chemical carcinogenesis in rats. Cancer prevention applications in humans, however, have not yet been tested in clinical trials. The injection of PEG 2000 into the bloodstream of guinea pigs after spinal cord injury leads to rapid recovery through molecular repair of nerve membranes. The effectiveness of this treatment to prevent paraplegia in humans after an accident is not known yet.  PEG is being used in the repair of motor neurons damaged in crush or laceration incidents in vivo and in vitro. When coupled with melatonin, 75% of damaged sciatic nerves were rendered viable.

Chemical uses

 Polyethylene glycol has a low toxicity and is used in a variety of products. The polymer is used as a lubricating coating for various surfaces in aqueous and non-aqueous environments. Since PEG is a flexible, water-soluble polymer, it can be used to create very high osmotic pressures (on the order of tens of atmospheres). It also is unlikely to have specific interactions with biological chemicals. These properties make PEG one of the most useful molecules for applying osmotic pressure in biochemistry and biomembranes experiments, in particular when using the osmotic stress technique. Polyethylene glycol is also commonly used as a polar stationary phase for gas chromatography, as well as a heat transfer fluid in electronic testers.

PEO (polyethylene oxide) can serve as the separator and electrolyte solvent in lithium polymer cells. Its low diffusivity often requires high temperatures of operation, but its high viscosity – even near its melting point – allows very thin electrolyte layers to be created. While crystallization of the polymer can degrade performance, many of the salts used to carry charge can also serve as a kinetic barrier to the formation of crystals. Such batteries carry greater energy for their weight than other lithium ion battery technologies.

 PEG has also been used to preserve objects that have been salvaged from underwater, as was the case with the warship Vasa in Stockholm,[18] the Mary Rose in England and the Ma'agan Michael Ship in Israel. It replaces water in wooden objects, making the wood dimensionally stable and preventing warping or shrinking of the wood when it dries. In addition, PEG is used when working with green wood as a stabilizer, and to prevent shrinkage. PEG is often used (as an internal calibration compound) in mass spectrometry experiments, with its characteristic fragmentation pattern allowing accurate and reproducible tuning.

PEG derivatives, such as narrow range ethoxylates, are used as surfactants.

PEG has been used as the hydrophilic block of amphiphilic block copolymers used to create some polymersomes.

Biological uses

 PEG is commonly used as a precipitant for plasmid DNA isolation and protein crystallization. X-ray diffraction of protein crystals can reveal the atomic structure of the proteins. Polymer segments derived from PEG polyols impart flexibility to polyurethanes for applications such as elastomeric fibers (spandex) and foam cushions. In microbiology, PEG precipitation is used to concentrate viruses. PEG is also used to induce complete fusion (mixing of both inner and outer leaflets) in liposomes reconstituted in vitro. Gene therapy vectors (such as viruses) can be PEG-coated to shield them from inactivation by the immune system and to de-target them from organs where they may build up and have a toxic effect. The size of the PEG polymer has been shown to be important, with larger polymers achieving the best immune protection.

 PEG is a component of stable nucleic acid lipid particles (SNALPs) used to package siRNA for use in vivo. In blood banking, PEG is used as a potentiator to enhance detection of antigens and antibodies.  When working with phenol in a laboratory situation, PEG 300 can be used on phenol skin burns to deactivate any residual phenol.

Commercial uses

 PEG is the basis of many skin creams (as cetomacrogol) and personal lubricants (frequently combined with glycerin). PEG is used in a number of toothpastes as a dispersant. In this application, it binds water and helps keep xanthan gum uniformly distributed throughout the toothpaste. PEG is also under investigation for use in body armor, and in tattoos to monitor diabetes. In low-molecular-weight formulations (i.e. PEG 400), it is used in Hewlett-Packard designjet printers as an ink solvent and lubricant for the print heads. PEG is also one of the main ingredients in paintball fills, due to its thickness and flexibility. However, as early as 2006, some Paintball manufacturers began substituting cheaper oil-based alternatives for PEG.[citation needed]

 PEG is a major ingredient in e-liquid, used in electronic cigarettes. It is generally used as a 30%–50% proportion of the liquid that is vaporized. Its use is designed to give a smoother effect to the vaporizing action. PEG is also used as an anti-foaming agent in food – its INS number is 1521 or E1521 in the EU.

Industrial uses

 Nitrate ester-plasticized polyethylene glycol is used in Trident II ballistic missile solid rocket fuel. Dimethyl ethers of PEG are the key ingredient of Selexol, a solvent used by coal-burning, integrated gasification combined cycle (IGCC) power plants to remove carbon dioxide and hydrogen sulfide from the gas waste stream. PEG has been used as the gate insulator in an electric double-layer transistor to induce superconductivity in an insulator. PEG is also used as a polymer host for solid polymer electrolytes. Although not yet in commercial production, many groups around the globe are engaged in research on solid polymer electrolytes involving PEG, with the aim of improving their properties, and in permitting their use in batteries, electro-chromic display systems, and other products in the future. PEG is used as a binder in the preparation of technical ceramics.

Choose from CARBOWAX™ PEGs in a variety of molecular weights, viscosities and in several physical forms. Each product grade is designated numerically by its average molecular weight. For example, CARBOWAX™ PEG 600 consists of a distribution of polymers of varying molecular weights with an average of 600. Molecular weight has an effect on the physical properties of each product grade. Increased molecular weight results in decreased solubility in water and solvents, decreased hygroscopicity and vapor pressure, and increased melting/freezing range and viscosity.

CARBOWAX™ SENTRY™ PEGs are available in average molecular weights ranging from 300 to 8000 in a variety of viscosities and physical forms. CARBOWAX™ SENTRY™ PEGs meet all applicable requirements in the National Formulary (NF) for use in drug applications, Food Chemicals Codex (FCC) requirements for use in certain food applications and personal care products.

สอบถามข้อมูลเพิ่มเติมได้ที่ ฝ่ายขาย

Thai Poly Chemicals Co., Ltd.

บริษัท ไทยโพลีเคมิคอล จำกัด

ที่อยู่36/5 ม.9  แขวง/ตำบลนาดี  เขต/อำเภอเมืองสมุทรสาคร  จังหวัดสมุทรสาคร รหัสไปรษณีย์74000

Tel.: 034854888, 034496284

Fax.: 034854899, 034496285

Mobile: 0824504888, 0800160016

Website : www.thaipolychemicals.com

Email1 : thaipolychemicals@hotmail.com

Email2 : info@thaipolychemicals.com

 

 


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